easyJet will introduce a new year-round domestic route from Birmingham Airport to Glasgow Airport in the spring of 2020.
The new connection will start on 29 March and operate 13 times a week between the two cities.
The short flight is expected to be especially popular amongst those travelling on business and commuters travelling between the two major UK cities.
easyJet started flying from Birmingham in December 2007 with its route to Geneva and has since added services to Belfast.
easyJet expects to carry 180,000 passengers in the first year alone operating on its Airbus A319 and A320 aircraft.